Tag: M.W:200-300

1271-55-2, Acetylferrocene is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of pure TsNHNH2 (15 mmol) in methanol (30 mL) was stirred and heated to 60 C until the TsNHNH2 dissolved. The mixture was cooled to room temperature. Then a solution of acetyl ferrocene 1a (10 mmol) in methanol was dropped into the mixture slowly. After approximately 0.5 h, the crude products could be obtained as solid precipitate. The precipitate was washed with petroleum ether then removed in vacuo to give yellow solid 2a in 86 % yield. mp 187-189 C. 1H NMR (500 MHz, DMSO) delta 10.00 (s,1H), 7.81 (d, J = 7.9 Hz, 2H), 7.43 (d, J = 7.8 Hz, 2H), 4.49 (s, 2H), 4.29 (s, 2H), 3.93 (s, 5H), 2.36 (s, 3H), 2.04 (s, 3H). 13C NMR (126 MHz, DMSO) d 155.1, 143.0, 136.4, 129.1, 127.6, 69.6, 68.9, 66.8, 20.9, 15.0. HRMS (ESI-TOF) m/z: [M]+ calcd. for C19H20FeN2O2S 396.0595; Found: 396.0594.

1271-55-2, As the paragraph descriping shows that 1271-55-2 is playing an increasingly important role.

Reference£º
Article; Ling, Li; Hu, Jianfeng; Zhang, Hao; Tetrahedron; vol. 75; 17; (2019); p. 2472 – 2481;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1271-51-8,Vinylferrocene,as a common compound, the synthetic route is as follows.

General procedure: A stirred mixture of bromo compound (1.0 equiv.), Pd(OAc)2 (0.1/0.2 equiv.) in dry DMF (25mL) under nitrogen was successively treatedwith K2CO3 (3.0/6.0 equiv.) and tetrabutylammoniumbromide (0.1/0.2equiv.)and stirred for 30 min. The vinyl dendron (1.0/2.0 equiv.)wasthen added and the resulting mixture was stirred at 90 ¡ãC for 12 h,cooled and filtered. The filtrate was evaporated to dryness in vacuo.The residue was extracted with CHCl3 (3 ¡Á 100 mL), washed withwater (3 ¡Á 100 mL) and dried over anhydrous Na2SO4. Evaporation ofthe organic layer afforded the crude product,whichwas purified by columnchromatography using the eluent as mentioned under each compoundto afford the corresponding conjugated dendrimers.

1271-51-8, The synthetic route of 1271-51-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ravivarma, Mahalingam; Kumar, Kaliamurthy Ashok; Rajakumar, Perumal; Pandurangan, Arumugam; Journal of Molecular Liquids; vol. 265; (2018); p. 717 – 726;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

1271-51-8, Vinylferrocene is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Vinylferrocene (1.50 g, 7.07 mmol), 4-iodobenzaldehyde(0.684 g, 2.95 mmol), palladium(II) acetate (0.0331 g,0.147 mmol) and tri-o-tolyl-phosphine (0.224 g, 0.767 mmol) weredissolved in a 1:10 solution (v/v) of triethylamine and acetonitrile (30 ml). The dark red reaction mixturewas stirred under N2 at 82 Cfor 24 h. After cooling, the solvent was removed and resulting redresidue was dissolved in 25 ml DCM and 25 ml water added. Theorganic layer was separated and the aqueous layer washed withDCM (3 25 ml). The organic fractions were combined, stirred overanhydrous MgSO4 and removed by gravity filtration. The filtratewas collected and the solvent removed to give a dark red residue.The product was purified by column chromatography, initially usinga solvent system of 100percent petroleum ether, followed by 50:50mixture of petroleum ether (40-60 C) and DCM. The desiredproduct (1) was isolated as a dark red powder (0.680 g, 73percent). Mp:decomposition without melting, onset at 110 C. 1H NMR(399.951 MHz, CDCl3): d (ppm) 9.97 (s, 1H, CHO), 7.83 (d, 2H,J 8.3 Hz, ArH), 7.56 (d, 2H, J 8.4 Hz, ArH), 7.07 (d, 1H, J 16.1 Hz,HC]CH), 6.73 (d, 1H, J 16.1 Hz, HC]CH), 4.51 (t, 2H, Cp), 4.35 (t,2H, Cp), 4.16 (s, 5H, Cp). 13C{1H} NMR (100.635 MHz, CDCl3):d (ppm) 191.55, 144.07, 134.67, 131.52, 130.32, 126.07, 124.60,82.25, 69.76, 69.38, 67.37. IR (KBr, cm1) n 1693 (C]O), 1630 (C]C). EI-MS: m/z 316 ([M], 100percent). Elemental Analysis forC19H16FeO0.5H2O calculated C, 70.18; H, 5.27, found C, 70.39; H,5.07percent.

1271-51-8, As the paragraph descriping shows that 1271-51-8 is playing an increasingly important role.

Reference£º
Article; Baartzes, Nadia; Stringer, Tameryn; Seldon, Ronnett; Warner, Digby F.; De Kock, Carmen; Smith, Peter J.; Smith, Gregory S.; Journal of Organometallic Chemistry; vol. 809; (2016); p. 79 – 85;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

Ferrocenemethanol, cas is 1273-86-5, it is a common heterocyclic compound, the iron-catalyst compound, its synthesis route is as follows.,1273-86-5

To a 10 ml Schlek reaction tube under a high-purity nitrogen atmosphere was added 0.20 mmol of benzoquinoline triphenylphosphine iridium hydrogen (16), lmmol of phenylacetylene, 2.3 mmol of ferrocene methanol, 0.8 mmol of sodium hydroxide and 3 ml of dioxane were charged. The reaction tube was replaced with nitrogen three times and then heated to 110 C with an oil bath under magnetic stirring. The reaction was refluxed for 36 hours. The filtrate was concentrated using a rotary evaporator and the remaining residue was purified by chromatography on oil (100 mL). The residue was purified by flash chromatography on silica gel eluting with an oil bath and the bath was cooled to room temperature. Ether as eluent, and separated by silica gel thin layer chromatography to obtain pure product 1-ferrocenyl-3-phenyl-1-propanone in a yield of 96%.

As the rapid development of chemical substances, we look forward to future research findings about 1273-86-5

Reference£º
Patent; Luoyang Normal University; Li, Xiao Dong; Li, gongmei; Xu, Chen; Hao, Xin Qi; Xiao, Zhi Qiang; (10 pag.)CN103242372; (2016); B;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1273-86-5,Ferrocenemethanol,as a common compound, the synthetic route is as follows.

General procedure: To a mixture of 1.0 mmol of ferrocenylcarbinol and 1.0 mmol of the corresponding heterocycle in 1.0 ml of methylene dichloride, 0.18 ml of 45 % aqueous solution of fluoroboric acid was added under vigorous stirring. The agitation was continued for 5 min then Et2O (15 ml), the same amount of cold water, and 5-10 mg of ascorbic acid were added to the reaction flask. After vigorous shaking of the mixture the organic solution was separated, washed with cold water (3¡Á15 ml), the solvent was removed and the residue was dried over CaCl2. All types of products (pyrrolidine as well as imidazolidine and thiazolidine derivatives) were equally purified, namely by column chromatography (silica, eluent hexane EtOAc 3:1), and solids obtained after chromatography were crystalized from ethanol.

1273-86-5, The synthetic route of 1273-86-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Rogatkina, Elena Yu.; Ivanova, Anna S.; Rodionov, Alexey N.; Peregudov, Alexander S.; Korlyukov, Alexander A.; Volodin, Alexander D.; Belousov, Yury A.; Simenel, Alexander A.; Arkivoc; vol. 2018; 5; (2018); p. 272 – 282;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

1271-51-8, Vinylferrocene is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

About 424 mg (about 2 mmol) of vinylferrocene, about 312 mg (about 0.5 mmol) of tris(4-iodophenyl)amine and about 7 mg (about 6 mol percent) of palladium acetate were placed in a flask. After a reflux condenser was connected to the flask, about 3 ml of 1,4-dioxene as a solvent, about 480 mul (about 2 mmol) of tri-n-butylamine as a base and about 11 mul (about 9 mol percent) of tri-t-butylphosphine were injected into the flask using a syringe under a nitrogen atmosphere. The solution was degassed with nitrogen gas, and refluxed in an oil bath. The reaction was allowed to proceed for about 4 days. The reaction solution was diluted with about 10 ml of methylene chloride and neutralized with a saturated aqueous solution of ammonium chloride. The neutralized solution was transferred to a separatory funnel, followed by phase separation. The obtained organic layer was dried over anhydrous magnesium sulfate and passed through a glass filter to obtain a transparent polymer solution. The polymer solution was evaporated under reduced pressure to remove the solvents. The residue was purified by column chromatography using toluene/hexane (1/2), yielding the metallocenyl dendrimer (about 301 mg) of Formula 2 as an orange solid. The 1H-NMR spectrum of the metallocenyl dendrimer is shown in FIG. 3., 1271-51-8

1271-51-8 Vinylferrocene 16211828, airon-catalyst compound, is more and more widely used in various fields.

Reference£º
Patent; Choi, Tae Lim; Lee, Kwang Hee; Lee, Sang Kyun; US2011/213172; (2011); A1;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1271-42-7,Ferrocenecarboxylic acid,as a common compound, the synthetic route is as follows.

Ferrocene (6.0 g, 32 mmol) and potassium tert-butoxide (0.46 g, 4.08 mmol) were completely dissolved in dry THF (300 mL). The orange solution was cooled to -78 0C when tertbutyllithium (34.0 mL, 64.5 mmol, 1 .9 M in pentane) was added dropwise over a period of 15 mm, with the temperature maintained below -70 00. The reaction mixture was stirred at -78Cfor 1 h and then poured on a slurry of dry ice (excess) and diethyl ether. The mixture was warmed to room temperature overnight and extracted with an aqueous solution of sodium hydroxide (0.75 N, 4 x 250 mL). The combined aqueous layers were neutralized with hydrochloric acid (pH > 4) and the resulting orange solid was extracted with Et20 (4 x 250 mL) until the organic layer remained colourless. The combined organic layers were filtered toremove traces of ferrocenedicarboxylic acid, dried over MgSO4, filtered and the solvent wasevaporated under reduced pressure to give ferrocenecarboxylic acidas an orange solid in35% yield. After suspending the ferrocenecarboxylic acid (462 mg, 2.01 mmol) in dry CH2CI2(23 mL), oxalyl chloride (1100 iL, 13.64 mmol) in dry CH2CI2 (10 mL) was added dropwise tothe reaction mixture whereby the orange suspension turned dark red. The reaction mixturewas refluxed for 2 h and then stirred overnight at room temperature. The solvent was thenremoved under vacuum. The product was not purified and used immediately for the next synthetic step.

1271-42-7, As the paragraph descriping shows that 1271-42-7 is playing an increasingly important role.

Reference£º
Patent; UNIVERSITAeT ZUeRICH; THE UNIVERSITY OF MELBOURNE; HESS, Jeannine; PATRA, Malay; GASSER, Gilles; JABBAR, Abdul; GASSER, Robin B.; WO2015/928; (2015); A1;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

Ferrocenemethanol, cas is 1273-86-5, it is a common heterocyclic compound, the iron-catalyst compound, its synthesis route is as follows.,1273-86-5

Compound hydroxymethylferrocene S5 (1 g, 4.63 mmol),1-chloro-3,5-di-p-chlorobenzoyloxy-2-deOxygen-D-ribose S6 (1.79 g, 4.17 mmol),Anhydrous Cs2CO3 (2.60 g, 7.87 mmol) was dissolved in anhydrous dichloromethane.Stir at room temperature overnight, and vortex off the solvent.Silica gel column chromatography(Dichloromethane: methanol = 95:5) was purified to give an orange-red compound S7 (yield: 80%).

As the rapid development of chemical substances, we look forward to future research findings about 1273-86-5

Reference£º
Patent; Hunan University; Tan Weihong; A Budula¡¤lazhate¡¤moyideng; (23 pag.)CN109265486; (2019); A;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

1273-86-5, Ferrocenemethanol is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Amine (1.0mmol), In(OTf)3 (0.1mmol) and anisyl alcohol (1.2mmol) were added into a flask. Then the mixture was vigorously stirred at reflux, until amine was completely consumed as indicated by TLC analysis or 24h. After the completion of reaction, CH2Cl2 (15mL¡Á2) was used to extract the product, the organic layer was dried with anhydrous Na2SO4. Then the solvent was evaporated under the reduced pressure. The residue was purified by flash column chromatography with ethyl acetate and petroleum ether as eluents to afford pure product. This procedure was followed for the synthesis of other N-benzylation amines.

1273-86-5, 1273-86-5 Ferrocenemethanol 10856885, airon-catalyst compound, is more and more widely used in various fields.

Reference£º
Article; Yang, Jin-Ming; Jiang, Ran; Wu, Lin; Xu, Xiao-Ping; Wang, Shun-Yi; Ji, Shun-Jun; Tetrahedron; vol. 69; 37; (2013); p. 7988 – 7994;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1273-86-5,Ferrocenemethanol,as a common compound, the synthetic route is as follows.

General procedure: Method A (Table 2, entries 1,4). Into a glass 50-mL flask equipped with a stirrer, a reflux condenser,a thermometer, a bubbler for propyne supply, and a gasoutlet, alcohol 1a,b (5.0 mmol), KPO0.5O2P (0.16 g, 2.5 mmol),and DMSO (30 mL) were placed. Propyne was passed on stirring for2 h through the reaction mixture heated up to 80 C. After coolingto room temperature the reaction mixture was diluted with anaqueous 1% solution of NH4Cl (50 mL) and extracted with ether(530 mL), the extracts were washed from DMSO by water(230 mL), dried over Na2SO4. Column chromatography (basicAl2O3, eluent hexane/diethyl ether with gradient from 1:0 to 3:1) ofthe crude residue after removal of the solvent gave the pure adducts2c,d and unreacted alcohols 1a,b.

1273-86-5, The synthetic route of 1273-86-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Trofimov, Boris A.; Oparina, Ludmila A.; Tarasova, Olga A.; Artem’ev, Alexander V.; Kobychev, Vladimir B.; Gatilov, Yuriy V.; Albanov, Alexander I.; Gusarova, Nina K.; Tetrahedron; vol. 70; 35; (2014); p. 5954 – 5960;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion