Tag: M.W:200-300

Name is Ferrocenemethanol, as a common heterocyclic compound, it belongs to iron-catalyst compound, and cas is 1273-86-5, its synthesis route is as follows.,1273-86-5

General procedure: Under a nitrogen atmosphere, ferrocenyl methanol (216 mg, 1 mmol) and 1-methylimidazole (240 mg, 3 mmol) were dissolved in 3 mL of acetic acid and stirred for 5 h at 60 C. Volatiles were evaporated, and a solution of NH4PF6 (1.11 g, 6.2 mmol) in EtOH (5 mL) was added. After the solution had been stirred for 2 h at room temperature, the solvent was evaporated. CH2Cl2 was added to the solution, and the solution was filtered through Celite. The solvent was removed, and the residues were recrystallization from acetone/ether afforded 0.30 g (71% yield) of 1b as yellow needles. 1H NMR (600 MHz, CD3COCD3): delta (ppm) 4.08 (s, 3H, CH3), 4.26 (s, 5H, C5H5), 4.33 (s, 2H, C5H4), 4.54 (s, 2H, C5H4), 5.44 (s, 2H, CH2), 7.71 (s, 1H, CH=CH), 7.76 (s, 1H, CH=CH), 9.01 (s, 1H, NCH=N). 13C NMR (400MHz, CD3COCD3): delta (ppm) 36.92 (CH3), 50.13 (CH2), 69.56, 69.96, 70.10, 80.54 (Cp-C), 122.87, 124.54, 136.59 (imidazole-C).

With the complex challenges of chemical substances, we look forward to future research findings about Ferrocenemethanol

Reference£º
Article; Kong, Dandan; Weng, Tanqing; He, Wenxue; Liu, Bin; Jin, Shan; Hao, Xiao; Liu, Shenghua; Journal of Organometallic Chemistry; vol. 727; (2013); p. 19 – 27;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

As a common heterocyclic compound, it belong iron-catalyst compound,Ferrocenecarboxylic acid,1271-42-7,Molecular formula: C11H10FeO2,mainly used in chemical industry, its synthesis route is as follows.,1271-42-7

In a 50mL three necks round bottom flask and under nitrogen atmosphere, 1mmol of ferrocenecarboxylic acid was dissolved in 15mL of dry dichloromethane at room temperature. To this solution, 170-200muL of oxalyl chloride was added dropwise and stirred overnight. The solution changed from orange to dark red. The reaction mixture was filtered in a fritted funnel and the filtrate collected. In a separate 100mL three necks round flask under nitrogen, 1.0mmol of the 4-X-phenol and 1.0mmol of pyridine were dissolved in 10-15mL of dichloromethane. To this solution, the ferrocenecarbonyl chloride solution prepared previously was added dropwise. The solution was stir 6-12hin the dark, under nitrogen atmosphere, and at room temperature. Thin layer chromatography (TLC) was used to monitor the reaction. After the reaction was finished, the mixture was filtered in a fritted funnel with a pad of celite. The filtrate collected was washed with 3¡Á5mL 1N HCl to remove pyridine and other by-products. The organic layer containing the compound was purified by column chromatography, using Silica gel and eluted with dichloromethane and isolated in 40-45% yield.

With the synthetic route has been constantly updated, we look forward to future research findings about Ferrocenecarboxylic acid,belong iron-catalyst compound

Reference£º
Article; Vera, Jose L.; Rullan, Jorge; Santos, Natasha; Jimenez, Jesus; Rivera, Joshua; Santana, Alberto; Briggs, Jon; Rheingold, Arnold L.; Matta, Jaime; Melendez, Enrique; Journal of Organometallic Chemistry; vol. 749; (2014); p. 204 – 214;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

Ferrocenemethanol, cas is 1273-86-5, it is a common heterocyclic compound, the iron-catalyst compound, its synthesis route is as follows.,1273-86-5

(3) Chlorinated ferrocene methane synthesis: under the protection of the helium, the ferrocene methanol (250 mg, 1 . 16 mmol) dissolved into dichloromethane (20 ml) in, then the oxalyl (6 drops, excess) into the wherein after then completing, in helium under the protection of the stirring 4 h, after the reaction, the solvent is removed by reduced pressure distillation, for fixing the residue water (10 ml) flushing.(4) Containing ferrocene group of the carbamate compound synthesis: amount taking 0. 6 Ml (1.0 mmol) is dissolved in carbon disulfide and 5 ml of ethanol, measuring the 2.4 g (1.0 mmol) di-n-octyl amine and 1.4 ml (i. the 0 1.0 mmol) triethylamine are added 1 a 50 ml three flasks; under the condition of the ice slowly dripping into carbon bisulfide ethanol solution, stirring 1 h; the removal of the ice bath, in the continuing stirring at room temperature 2 h; then adding 0.25 g (1.0 mmol) chloro ferrocene methane ethanol solution of 10 ml, to control the temperature 5 C following reaction 1 h, then raising the stirring to reflux 2 h; TLC monitoring the reaction, solvent system as developing solvent (benzene and acetone of volume ratio of 1:1); boil off ethanol, adding anhydrous ethyl ether 20 ml, filtering out the deposit, the filtrate water washing 3 times, then the molecular sieve drying, filtering, the steamed ethyl ether to obtain yellow solid, yield 82. 8%, Melting point 100 – 102 C.

1273-86-5 is used more and more widely, we look forward to future research findings about Ferrocenemethanol

Reference£º
Patent; Shandong Yuangen Petrochemical Co., Ltd.; Qiao Liang; Yuan Junzhou; Song Laigong; He Jingsong; Liu Shanshan; (7 pag.)CN104710482; (2018); B;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1271-51-8,Vinylferrocene,as a common compound, the synthetic route is as follows.

General procedure: In a 25-mL round-bottomed flask, a mixture of aryl iodide (5 mmol), alkene (6 mmol), and base (5.6 mmol) was placed in 4 mL of DMF, then a solution of the complex 3 (0.005 mol percent) in 1 mL of DMF was added. The reaction mixture was refluxed for the time stated in Tables 3 and 4 at 140 ¡ãC. The reaction mixture was poured into water (20 mL) and extracted with ether or hexane (2¡Á30 mL). The combined organic layers were dried over anhydrous sodium sulfate. After the removal of the solvent in vacuo, the resulting crude was purified by column chromatography on silica gel (hexane/ethyl acetate) to give the corresponding cross-coupling product (the purified product was identified by means of determination of mp and by 1H and 13C NMR, the data obtained are consistent with literature).26 The entire flasks used in the each coupling reaction were meticulously cleaned with aqua regia to avoid the presence of unseen palladium catalyst.

1271-51-8, As the paragraph descriping shows that 1271-51-8 is playing an increasingly important role.

Reference£º
Article; Sua?rez-Meneses, Jesu?s V.; Bonilla-Reyes, Edgar; Ble?-Gonza?lez, Ever A.; Ortega-Alfaro, M. Carmen; Toscano, Rube?n Alfredo; Cordero-Vargas, Alejandro; Lo?pez-Corte?s, Jose? G.; Tetrahedron; vol. 70; 7; (2014); p. 1422 – 1430;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

Ferrocenemethanol, cas is 1273-86-5, it is a common heterocyclic compound, the iron-catalyst compound, its synthesis route is as follows.,1273-86-5

General procedure: To a solution of ferrocenyl alcohol 1 or 2 (2.0 mmol) and correspondingmercapto derivative in dry MeNO2 (5 mL) CAN (22 mg,0.04 mmol, 0.2 mol%) was added. The resulting mixture was stirredat room temperature until TLC analysis revealed complete disappearanceof starting alcohol 1 or 2 (usually 3-4 h). Then reactionmixture was poured onto a water (40 mL), organic layer was separated,the aqueous phase was extracted with EtOAc (2 10 mL),and the combined organic solution was dried over Na2SO4, filteredand the solvents were evaporated in vacuo. The remained productwas treated with CH2Cl2 (50 ml) and passed through a silica gellayer (2.5 cm) on the filter to give corresponding products 5-9,11 after the evaporation of volatiles at reduced pressure.

1273-86-5 is used more and more widely, we look forward to future research findings about Ferrocenemethanol

Reference£º
Article; Ol’shevskaya, Valentina A.; Makarenkov, Anton V.; Borisov, Yury A.; Ananyev, Ivan V.; Kononova, Elena G.; Kalinin, Valery N.; Ponomaryov, Andrey B.; Polyhedron; vol. 141; (2018); p. 181 – 190;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1271-51-8,Vinylferrocene,as a common compound, the synthetic route is as follows.

Add 1t (0.2 mmol, 42mg) of vinyl ferrocene, 2a (0.2 mmol, 29 muL), toluene (1 mL), and Cp to the reaction tube in this order.2ZrH2(0.01 mmol, 2.3 mg). Stir the reaction at room temperature under a nitrogen (1 atm) atmosphere.GC detection until the reaction is complete.Filter through celite, spin dry the solvent under reduced pressure, and purify the residue by silica gel column chromatography. Use petroleum ether: ethyl acetate (40 mL: 1 mL) as the eluent to obtain ferrocene vinyl boric acid as a yellow oil Pinacol ester 3t (63mg, 80%).

1271-51-8, 1271-51-8 Vinylferrocene 16211828, airon-catalyst compound, is more and more widely used in various fields.

Reference£º
Patent; Chinese Academy Of Sciences Lanzhou Chemical Physics Institute; Wu Lipeng; Shi Xiaonan; (17 pag.)CN110483561; (2019); A;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

As a common heterocyclic compound, it belongs to iron-catalyst compound, name is Ferrocenemethanol, and cas is 1273-86-5, its synthesis route is as follows.,1273-86-5

General procedure: To a solution of ferrocenyl alcohol 1 or 2 (2.0 mmol) and correspondingmercapto derivative in dry MeNO2 (5 mL) CAN (22 mg,0.04 mmol, 0.2 mol%) was added. The resulting mixture was stirredat room temperature until TLC analysis revealed complete disappearanceof starting alcohol 1 or 2 (usually 3-4 h). Then reactionmixture was poured onto a water (40 mL), organic layer was separated,the aqueous phase was extracted with EtOAc (2 10 mL),and the combined organic solution was dried over Na2SO4, filteredand the solvents were evaporated in vacuo. The remained productwas treated with CH2Cl2 (50 ml) and passed through a silica gellayer (2.5 cm) on the filter to give corresponding products 5-9,11 after the evaporation of volatiles at reduced pressure.

With the complex challenges of chemical substances, we look forward to future research findings about 1273-86-5,belong iron-catalyst compound

Reference£º
Article; Ol’shevskaya, Valentina A.; Makarenkov, Anton V.; Borisov, Yury A.; Ananyev, Ivan V.; Kononova, Elena G.; Kalinin, Valery N.; Ponomaryov, Andrey B.; Polyhedron; vol. 141; (2018); p. 181 – 190;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1271-51-8,Vinylferrocene,as a common compound, the synthetic route is as follows.

General procedure: A deoxygenated mixture of vinylferrocene (170mg, 0.80mmol), K2CO3 (1.50g, 11mmol), tetrabutylammonium bromide (1.19g, 3.70mmol), bromochromone (0.66mmol) and Pd(OAc)2 (20mg, 0.09mmol) in DMF (23ml) was heated at 95¡ãC for 19h. After cooling to r. t. the reaction mixture was evaporated to dryness. Solid residue was dissolved in chloroform and extracted several times with water. The organic phase was dried with MgSO4, filtered and the solvent was removed from the filtrate in vacuo. The residue was subjected to chromatography on SiO2 (eluent: CHCl3/methanol, 50:2). Finally the analytically pure products were obtained after recrystallization from chloroform/n-hexane mixture.

1271-51-8, The synthetic route of 1271-51-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kowalski, Konrad; Koceva-Chy, Aneta; Szczupak, Lukasz; Hikisz, Pawel; Bernasin?ska, Joanna; Rajnisz, Aleksandra; Solecka, Jolanta; Therrien, Bruno; Journal of Organometallic Chemistry; vol. 741-742; 1; (2013); p. 153 – 161;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

As a common heterocyclic compound, it belong iron-catalyst compound,Ferrocenemethanol,1273-86-5,Molecular formula: C11H3FeO,mainly used in chemical industry, its synthesis route is as follows.,1273-86-5

General procedure: To a mixture of 1.0 mmol of ferrocenylcarbinol and 1.0 mmol of the corresponding heterocycle in 1.0 ml of methylene dichloride, 0.18 ml of 45% aqueous solution of fluoroboric acid was added under vigorous stirring. The agitation was continued for 5 min then Et2O (15 ml), the same amount of cold water, and 5-10 mg of ascorbic acid were added to the reaction flask. After vigorous shaking of the mixture the organic solution was separated, washed with cold water (5 15 ml), the solvent was removed and the residue was dried over CaCl2. 3-Ferrocenylmethylbenzo[d]thiazole-2(3H)-thione (5a) Yield 47%. Dark brown crystals, m.p. 134-135 C. Anal.: ? 59.27; ? 4.09; N 3.80; S 17.50%. Calc. for ?18?15FeNS2: ? 59.18; ? 4.14; N 3.83; S 17.56%. EI/MS, m/z (RI%): 365 [M]+ (78). 1? NMR (CDCl3, delta, ppm): 4.12 (s, 2H, Fc), 4.24 (s, 5H, Fc), 4.51 (s, 2H, Fc), 5.44 (s, 2H, CH2), 7.32-7.42 (m, 4H, Het). 13C NMR (CDCl3, delta, ppm): 45.5 (CH2), 68.4 (C5H4), 69.0 (C5H5), 69.9 (C5H4), 81.2 (ipso-C5H4), 112.8 (C-4, Het), 121.3 (C-7, Het), 124.7 (C-6, Het), 126.8 (C-5, Het), 127.6 (C-8, Het), 141.3 (C-9, Het), 189.1 (C=S).

With the synthetic route has been constantly updated, we look forward to future research findings about Ferrocenemethanol,belong iron-catalyst compound

Reference£º
Article; Rodionov, Alexey N.; Zherebker, Kira Ya.; Snegur, Lubov V.; Korlyukov, Alexander A.; Arhipov, Dmitry E.; Peregudov, Alexander S.; Ilyin, Mikhail M.; Nikitin, Oleg M.; Morozova, Nataliya B.; Simenel, Alexander A.; Journal of Organometallic Chemistry; vol. 783; (2015); p. 83 – 91;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

Name is Acetylferrocene, as a common heterocyclic compound, it belongs to iron-catalyst compound, and cas is 1271-55-2, its synthesis route is as follows.,1271-55-2

General procedure: To a solution of acetyl ferrocene (0.34 g, 2.5 mmol) and correspondingactive aldehyde (2.5 mmol) in dry ethanol (20 ml) takenin a beaker (100 ml), a catalytic quantity of potassium hydroxide(0.05 g, 1.25 mmol)was added and the reaction mixturewas heatedinside a microwave oven for 54e68 s (at 210W, i.e. ~30% microwavepower) [25]. After complete the reaction mixture was cooled in anice bath and the product thus formed were filtered, washed withethanol followed by washing with water till the washings wereneutral and recrystallized from distilled ethanol and chloroform(Scheme 1 and Table 1).

With the complex challenges of chemical substances, we look forward to future research findings about Acetylferrocene

Reference£º
Article; Khan, Salman A.; Asiri, Abdullah M.; Al-Ghamdi, Najat Saeed M.; Zayed, Mohie E.M.; Sharma, Kamlesh; Parveen, Humaira; Journal of Molecular Structure; vol. 1139; (2017); p. 137 – 148;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion