Tag: M.W:100-200

102-54-5, Ferrocene is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,102-54-5

General procedure: A solution 3-5mmol of ferrocene in dichloromethane (DCM) or dichloroethane (DCE) (3-5mL) was prepared. A previously prepared solution of 1equivalent of acyl chloride and 1equivalent of aluminum chloride in DCM or DCE (3-5mL) was transferred to the ferrocene solution, while stirring and with positive nitrogen pressure. The mix of the two liquids generated an intense purple or blue mixture. Reaction was stopped after 30-60min of stirring at room temperature. An equal quantity of water was added to the reaction mixture. The organic phase was separated and the aqueous phase was extracted with methyl t-butyl ether (MTBE), and the combined organic phase was dried over anhydrous sodium sulfate. The solvent was removed and the crude product (red to orange solid) was purified by column chromatography column on silica gel (230-400mesh) with a gradient of cyclohexane-benzene as eluent.

As the paragraph descriping shows that 102-54-5 is playing an increasingly important role.

Reference£º
Article; Garcia-Barrantes, Pedro M.; Lamoureux, Guy V.; Perez, Alice L.; Garcia-Sanchez, Rory N.; Martinez, Antonio R.; San Feliciano, Arturo; European Journal of Medicinal Chemistry; vol. 70; (2013); p. 548 – 557;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

102-54-5, Ferrocene is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

102-54-5, Weigh 5.59g (30mmol) ferrocene was added to 250mL two-necked flask, and then weighed 24mL (254mmol) of acetic anhydride was added to the flask, and then weighed 7mL (including H3PO4 121mmol) 85% phosphoric acid was added slowly to the flask.Temperature was raised to 75 ~ 80C for about 10min, then the flask was immediately cooled in an ice bath, was added to the flask to about 30mL of ice water.After a short cooling with 25% NaOH solution to neutral, a large tan solid precipitated, cooling was continued for some time and the filter cake was washed with an amount of ice water, dry.The crude product is purified by column chromatography (dichloromethane / petroleum ether (60-90) eluting the solvent was evaporated to give an orange solid ferrocene ethyl ketone product 5.30g, yield 77.1% (ferrocene meter ), melting point 83 ~ 85C.

As the paragraph descriping shows that 102-54-5 is playing an increasingly important role.

Reference£º
Patent; Huazhong Agricultural University; Ma, Jingzhong; Yan, Xinwen; Ma, Zhonghua; Jiang, Hong; Yang, Qiuhong; He, Mengli; (18 pag.)CN103626805; (2016); B;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.102-54-5,Ferrocene,as a common compound, the synthetic route is as follows.

A mixture of 5.3g (28mmol) ferrocene and 60mL chloroform was placed in a 50mL three-neck flask and kept at-5 to-10C. Afterward, 10.5mL phosphorus oxychloride dissolved in 15mL DMF was added for 1.5h. The resulting reaction mixture was refluxed for 12h. After solvent removal, the product was poured into 100mL ice water and filtered. The filtrate was neutralized to pH 8-9 using NaOH (10%, w/v) and then extracted with ether. The organic layer was washed with water and dried over anhydrous MgSO4. After removal of the solvent, the crimson solid was recrystallized from n-hexane. The purified product (1) weighed 2.3g (79% yield). 1H NMR(CDCl3): delta, 9.95 (s, 1H, HC=O), 4.79-4.80 (d, 2H, Cp-rings), 4.60-4.61(d, 2H, Cp-rings), 4.28(s, 5H, Cp?-rings). MS(ESI), m/z: 215.0 (M+) FT-IR (KBr): upsilon (cm-1) 1681(C=O)., 102-54-5

The synthetic route of 102-54-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Jia, Jianhong; Cui, Yanhong; Li, Yujin; Sheng, Weijian; Han, Liang; Gao, Jianrong; Dyes and Pigments; vol. 98; 2; (2013); p. 273 – 279;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

Ferrocene, cas is 102-54-5, it is a common heterocyclic compound, the iron-catalyst compound, its synthesis route is as follows.

General procedure: A solution of acid chloride (63 mmol) in 30 mL drydichloromethane was added to a suspension of anhydrousaluminum chloride (8.41 g, 63 mmol) in 30 mLdry dichloromethane, and the mixture was stirred at 5 Cfor 1 h under Argon. The solution of aluminum chloride/acid chloride complex was added dropwise over 30 minto a solution of ferrocene (11.16 g, 60 mmol) in 100 mLdry dichloromethane at 0 C. The reaction mixture waswarmed to room temperature and stirred for 16 h. A solutionof NaBH4(2.38 g, 63 mmol) in 25 mL diglyme wasadded dropwise to the purple reaction mixture at -5 C. Anorange solution was formed and stirred at 0 C for 1 h. Themixture was then hydrolyzed with addition of 20 mL waterwhile maintaining its temperature at less than or equal to10 C. The mixture was allowed to separate by settling,and the organic phase was then withdrawn. The aqueousphase was extracted with 3 times 30 mL of dichloromethane,and then all the organic phases are combined. Combinedorganic layer was washed with 50 mL of brine. Afterthe drying of organic layer on the Na2SO4,dichloromethanewas distilled under atmospheric pressure. The diglymeand the residual ferrocene which was found to be entrainedby the diglyme were then distilled at reduced pressureapproximately 20 mm Hg and a column head temperatureof 85-95 C. The alkylferrocene derivatives were distilledat a more reduced pressure, less than 5 mm Hg., 102-54-5

As the rapid development of chemical substances, we look forward to future research findings about 102-54-5

Reference£º
Article; Teimuri-mofrad, Reza; Safa, Kazem D.; Abedinpour, Saiedeh; Rahimpour, Keshvar; Journal of the Iranian Chemical Society; vol. 14; 10; (2017); p. 2177 – 2185;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

102-54-5, Ferrocene is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,102-54-5

General procedure: A solution of acyl chloride (53.76 mmol) in 25 ml drydichloromethane was added to a suspension of anhydrousaluminum chloride (7.7 g, 53.76 mmol) in 25 ml drydichloromethane and the mixturewas stirred at 5 C for 1 hunder argon. The solution of aluminum chloride/acyl chloridecomplexwas added dropwise for 30 min to a solution offerrocene (10 g, 53.76 mmol) in 130ml dry dichloromethaneat 0 C. The reaction mixture was warmed to room temperatureand stirred for 16 h. A solution of NaBH4 (2.29 g,53.76 mmol) in 25 ml diglyme was added dropwise to thepurple reaction mixture at 5 C to form an orange solutionas the result which was stirred for an hour in 0 C. Themixture was hydrolyzed with water while maintaining itstemperature at less than or equal to 10 C. The mixture wasallowed to separate by settling and the organic phase wasthen withdrawn. The aqueous phase was extracted 3 timeswith 30 ml of CH2Cl2 and then all the organic phases werecombined,washed with 50 ml of brine, CH2Cl2was removedand the diglyme and the residual ferrocene which wasfound to be entrained by the diglyme, were distilled atreduced pressure of approximately 20 mm Hg at a columnhead temperature of 85 Ce95 C. The alkylferrocene derivativeswere distilled, at less than 5mmHg. Specific detailsare given for each compound.

102-54-5 Ferrocene 7611, airon-catalyst compound, is more and more widely used in various fields.

Reference£º
Article; Teimuri-Mofrad, Reza; Mirzaei, Farzaneh; Abbasi, Hassan; D. Safa, Kazem; Comptes Rendus Chimie; vol. 20; 2; (2017); p. 197 – 205;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.102-54-5,Ferrocene,as a common compound, the synthetic route is as follows.,102-54-5

To a solution of ferrocene (1; 5.00 g, 26.87 mmol) in anhydrous CH 2 Cl 2(30 mL), a solution of acetyl chloride (2.01 mL, 28.21 mmol) and AlCl 3(3.94 g, 29.55 mmol) in anhydrous CH 2 Cl 2 (40 mL) was added at 0 C.The reaction temperature was allowed to rise to r.t., and the dark-vio-let solution was stirred for 2 h. The reaction was quenched by addi-tion of ice-cold water (70 mL) at 0 C and the mixture was extractedwith CH 2 Cl 2 (3 ¡Á 70 mL). The collected organic layers were washedwith a solution of Na 2 CO 3 (50 mL), dried over Na 2 SO 4 , filtrated and thesolvent was removed under reduced pressure. Crude product (dark-orange solid) was purified by chromatography on SiO 2 (hexanes/EtOAc = 4:1; R f = 0.3) to afford target product 2.Yield: 4.45 g (73%); orange solid; mp 85-86 C (lit. 20 85-86 C).1 H NMR (300 MHz, CDCl 3 ): delta = 4.78-4.76 (m, 2 H), 4.55-4.42 (m, 2 H),4.20 (s, 5 H), 2.40 (s, 3 H).NMR spectra are in agreement with those of the commercially avail-able product.

102-54-5 Ferrocene 7611, airon-catalyst compound, is more and more widely used in various.

Reference£º
Article; Plevova, Kristina; Mudrakova, Brigita; ?ebesta, Radovan; Synthesis; vol. 50; 4; (2018); p. 760 – 763;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

A common heterocyclic compound, the iron-catalyst compound, name is Ferrocene,cas is 102-54-5, mainly used in chemical industry, its synthesis route is as follows.

Step (1): Under a nitrogen system,10 g (53.8 mmol) of ferrocene was first dissolved in 50 mL of anhydrous n-hexane,Further, 18.1 mL (84.5 mmol) of tetramethylethylenediamine (TMEDA) was added,And 48.0 mL of n-hexane solution of 2.5 M n-butyllithium (n-BuLi) was slowly added dropwise at 0 C,And stirred at 25 C. After stirring for 12 hours,Remove the solvent first,And the resulting pale orange yellow complex was added to 200 mL of ethyl ether and the mixture was stirred and cooled to -78 C,Slowly drop the iodine ether solution (19.0 g I2 / 350 mL)Ether)After slowly warming to 25 C and stirring for 1 hour,The reaction was poured into 100 mL,5 wt% aqueous solution of ferric chloride (FeCl3)And then extracted with 200 mL of ether,The resulting organic layer was washed 10 times with 5 wt% of ferric chloride (FeCl3) aqueous solution (100 mL)And then washing the organic layer with water to the water layer is no longer discolored,To remove water with anhydrous magnesium sulfate (MgSO4) and remove the solvent,To obtain a mixture of compound a and compound b in a dark brown and liquid form(The molar ratio of compounds a and b is 1: 1; compounds a and b are shown in reaction I). Step (2):2.5 g (6.67 mol) of the mixture obtained in step (1)128 mg (0.67 mmol) of cuprous iodide (CuI),107 mg (0.67 mmol) of ferric chloride (FeCl3),540 mg (13.3 mmol) of sodium hydroxide,30 mL of aqueous ammonia (15 M) and 30 mL of ethanol (EtOH) were placed in a 150 mL autoclave,And then reacted at 90 C for 12 hours and lowered to 25 C,200 mL of diethyl ether was poured and washed three times with 150 mL of a 1.0 M aqueous solution of sodium hydroxide,After removing water with anhydrous magnesium sulfate and removing the solvent,To obtain a crude orange-brown product.At last,The crude orange-brown product was purified by column chromatography using 1: 2 (v / v ethyl acetate and n-hexane)To obtain a yellowish amine ferrocene solid (yield 48%)., 102-54-5

As the rapid development of chemical substances, we look forward to future research findings about 102-54-5

Reference£º
Patent; Zheng, Jianhong; Lai, Zhenchang; Zhang, Yuwei; Liao, Chunyi; Huang, Minjie; (31 pag.)CN106317129; (2017); A;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

A common heterocyclic compound, the iron-catalyst compound, name is Ferrocene,cas is 102-54-5, mainly used in chemical industry, its synthesis route is as follows.

1. Mix acetic anhydride and phosphoric acid and stir at room temperature for 15 minutes;2, adding ferrocene solids, heated to 40 C for 1 hour;3. Raise the temperature to 50 C and react until the ferrocene reaction is complete;4. Quickly pour the reaction solution into crushed ice, adjust the pH to 6-7 with sodium bicarbonate solids, and filter to obtain acetylBasic ferrocene crude;5. Pure acetyl ferrocene is obtained by recrystallization from petroleum ether.In this example, acetic anhydride: phosphoric acid: ferrocene solids = 3:1:0.5.By elemental analysis tests, the product was confirmed to be acetylferrocene. The yield is above 95%.The reaction conditions for the synthesis of acetylferrocene are mild, the temperature is easy to control, and the preparation yield is high., 102-54-5

As the rapid development of chemical substances, we look forward to future research findings about 102-54-5

Reference£º
Patent; Suzhou Tianyun Metal Materials Co., Ltd.; Wang Ming; (5 pag.)CN107488200; (2017); A;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion