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Macro-sized diamond films have been widely applied as the electrode for electrochemical and electroanalytical applications. Due to the non-uniform doping in diamond, boundary effects, and the varied ratios of graphite to diamond, only averaged electrochemical signals are detected over the full electrode. The studies of diamond electrochemistry at the nanoscale are thus highly required. In this chapter we overview recent progress and achievements about electrochemical properties and applications of diamond nanostructures and nanoparticles. After a brief introduction of the formation of these nanostructures and nanoparticles, electrochemical behavior of diamond nanostructures (e.g., diamond nanotexures, nanowires, networks, etc.) and nanoparticles (undoped, doped nanoparticles) in the presence/absence of redox probes is summarized. Their electroanalytical (e.g., electrochemical, biochemical sensing, etc.) and electrochemical (e.g., energy storage using capacitors and batteries, electrocatalysis, etc.) applications are shown. Diamond nanoelectrode array is introduced and highlighted as a promising tool to investigate diamond electrochemistry at the nanoscale as well.

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Reference:
Iron Catalysis in Organic Synthesis | Chemical Reviews,
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

 

Archives for Chemistry Experiments of Hemin

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Hemin was assembled on the surface of single-walled carbon nanotubes (SWCNT) through non-covalent functionalization by pi-pi stacking. The resulting nanohybrid of hemin-SWCNT possessed an intrinsic peroxidase-like activity, and could effectively catalyze oxidation of the substrate 3,3,5,5-tetramethylbenzidine by H2O2 to develop a blue color in aqueous solution. The activity of hemin-SWCNT hybrid material was much higher than the activity of hemin alone. Combination of the catalytic reaction of glucose with glucose oxidase and the hemin-SWCNT hybrid catalytic reaction, a colorimetric method for glucose detection was also developed. The hemin-SWCNT nanohybrid also exhibited high stability and excellent reusability.

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Reference:
Iron Catalysis in Organic Synthesis | Chemical Reviews,
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

 

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Chemical research careers are more diverse than they might first appear, Synthetic Route of 1271-48-3, as there are many different reasons to conduct research and many possible environments. In a article, mentioned the application of 1271-48-3, Name is 1,1′-Ferrocenedicarboxaldehyde, molecular formula is C12H10FeO2

The capability of metallocene bridges as new organometallic magnetic couplers is evaluated by studying the family of diradicals 2 (M = Fe, Ru) consisting of two purely organic alpha-nitronyl aminoxyl radicals connected by a 1,1?-metallocenylene bridge. Preliminary studies performed with 2-metallocenyl-alpha-nitronyl aminoxyl monoradicals 1 (M = Fe, Ru, Os), as reference compounds, show the presence of a small spin density on the central metal of the metallocenes. This fact makes the metallocene units effective bridges to transmit magnetic interactions by a spin polarization mechanism. The study of the magnetic properties of diradicals 2 in the solid state and in diluted frozen solutions reveals the existence of an intramolecular antiferromagnetic exchange interaction between the radical subunits whose strength is highly dependent on the molecular conformation adopted by the diradical. As shown by crystal data and by ESR measurements, an intramolecular hydrogen bond between the two radical units forces the molecule to adopt a cisoid molecular conformation, which determines that the magnetic interaction occurs by a direct through-space interaction between the two SOMOs of the two radical units along with the classical spin polarization mechanism through the sigma-bonds of the metallocene unit. Lattice constants for both structures are as follows: 1 (M = Fe), C17H21FeN2O2, a = 7.170(1) A, b = 10.135(2) A, alpha = 10.683(2) A, alpha = 88.88(3), beta = 83.42(3), gamma = 79.75(3), triclinic, P1, Z = 2; 2 (M = Fe), C24H32FeN4O4, a = 11.848(3) A, b = 11.785(2) A, c = 17.728(4) A, beta = 106.25(2), monoclinic, P21/n, Z = 4.

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Reference:
Iron Catalysis in Organic Synthesis | Chemical Reviews,
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

 

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The efficiency of the alkaloids quinine, cinchonine, cinchonidine and ephedrine, the aminoalcohols prolinol, and alaninol, as well as the aminoacids proline, and phenylalanine as catalysts for the enantioselective addition of diethylzinc to ferrocene carbaldehyde and benzaldehyde has been studied. The addition reactions proceeded with acceptable yields and low to moderate enantioselectivities. The side products ferrocenyl methanol and 1-ferrocenyl-1- propanone, observed during the additions to ferrocene carbaldehyde were isolated and characterized.

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Reference:
Iron Catalysis in Organic Synthesis | Chemical Reviews,
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

 

Simple exploration of Vinylferrocene

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Cyclic azomethine imines possessing a beta-aminocarbonyl motif are accessed from simple alkene and hydrazone starting materials. A thermal, concerted alkene aminocarbonylation pathway involving an imino-isocyanate intermediate is proposed and supported by DFT calculations. A notable feature of the process is the steric shielding present in the dipoles formed, which allows for facile purification of the products by chromatography or crystallization. In addition, a fluorenone-derived reagent is reported, which provides reactivity with several alkene classes and allows for mild derivatization of the dipoles into beta-aminoamides, beta-aminoesters, and beta-amino acids.

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Reference:
Iron Catalysis in Organic Synthesis | Chemical Reviews,
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

 

Can You Really Do Chemisty Experiments About 1,1′-Diacetylferrocene

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Borane, as a DMS or a THF complex, can efficiently reduce a large range of ferrocenyl derivatives (aldehydes, ketones, ethers, acetals, carboxylic acids, esters,…) if they bear at least one oxygen at a carbon at the alpha position. On the contrary, similar molecules, which contain nitrogen instead of oxygen, do not react with borane.

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Reference:
Iron Catalysis in Organic Synthesis | Chemical Reviews,
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

 

What Kind of Chemistry Facts Are We Going to Learn About Ferrocenemethanol

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The alpha-ferrocenylalkyl carbenium ions are formed from ferrocene and carbonyl compounds in strongly acidic media, in particular mixtures of fluorosulfuric acid and trichloroacetic acid.The alpha-ferrocenylalkyl carbenium ions are scavenged by nucleophiles or bases.The addition of nucleophiles produces the corresponding alpha-substituted ferrocenyl alkanes.Proton abstraction by base from the beta-position leads to the ferrocenylethene derivatives.Such electrophilic substitutions of ferrocene by carbonyl compounds, followed by suitable scavengeing of the alpha-ferrocenylalkyl carbenium ion, form the basis of one-pot syntheses of various ferrocene derivatives.

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Iron Catalysis in Organic Synthesis | Chemical Reviews,
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

 

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MicroRNAs (MiRNAs) have been regarded as clinically important biomarkers and drug discovery targets. In this work, we reported a simple and ultrasensitive electrochemical method for miRNAs detection based on single enzyme amplification and electrochemical-chemical-chemical (ECC) redox cycling. Specifically, upon contact with the target miRNAs, the hairpin structure of biotinylated DNA immobilized on gold electrode was destroyed and the biotin group in DNA was forced away from the electrode surface, allowing for the coupling of streptavidin-conjugated alkaline phosphatase (SA-ALP). Then, ascorbic acid (AA, the enzymatic product of ALP) triggered the ECC redox cycling with ferrocene methanol (FcM) and tris(2-carboxyethyl)phosphine (TCEP) as the redox mediator and the chemical reducing reagent, respectively. The method was more sensitive than that with horseradish peroxidase (HRP) or glucose oxidase (GOx) triggered recycling since one ALP molecule captured by one target miRNA molecule promoted the production of thousands of AA. Analytical merits (e.g., detection limit, dynamic range, specificity, regeneration and reproducibility) were evaluated. The feasibility of the method for analysis of miRNA-21 in human serum has also been demonstrated.

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Iron Catalysis in Organic Synthesis | Chemical Reviews,
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

 

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alpha-Ferrocenylcarbinols, readily obtained by direct condensation of aldehydes or ketones with ferrocene, react smoothly with mercaptosuccinic acid to give ferrocenylmethylthiosuccinic acids.The optically active dimethyl (R)-mercaptosuccinate provides a way for the resolution of tertiary alcohols.

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Iron Catalysis in Organic Synthesis | Chemical Reviews,
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

 

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(Chemical Equation Presented). A simple, highly efficient, and general strategy for the direct synthesis of amino-(N-alkyl)benzenesulfonamides has been accomplished via direct N-alkylation of aminobenzenesulfonamides bearing both different types of amino groups with alcohols as alkylating agents. Notably, this research exhibited the potential for the recognition of different types of amino groups in the N-alkylation of complex molecules with alcohols, facilitating the progress of the transition-metal-catalyzed “hydrogen autotransfer (or hydrogen-borrowing) process.”

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Reference:
Iron Catalysis in Organic Synthesis | Chemical Reviews,
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion