Category: 1273-86-5

A common heterocyclic compound, the iron-catalyst compound, name is Ferrocenemethanol,cas is 1273-86-5, mainly used in chemical industry, its synthesis route is as follows.,1273-86-5

Ferrocenemethanol (2a, 0.020 g, 0.093 mmol) was dissolved in dichloromethane (0.4 mL) thio phenol (0.031 g, Place the 0.28 mmol). Fluoro boric acid solution to the solution put (48 wt%, 0.034 mL, 0.18 mmol). Mixed reactions After stirring for 5 minutes with water at room temperature, poured into a saturated aqueous solution of sodium bicarbonate (5 mL), place a dichloromethane (10 mL) Uh diluted. The organic layer was separated and extracted three times the remaining water layer with dichloromethane (10 mL x 3). Oil collected Group layer is washed with a saturated aqueous sodium chloride solution, placed into the over anhydrous sodium sulfate, filtered under reduced pressure. The solvent of the filtrate under reduced pressure After removing all column chromatography (hexane: ethyl acetate = 30: 1) to give compound 3a as a yellow solid (0.028 g, 98%).

As the rapid development of chemical substances, we look forward to future research findings about 1273-86-5

Reference£º
Patent; Diatech Korea Co. Ltd.; Sogang University Research Foundation; Moon, PongJin; Oh, HaNa; Kang, NaNa; Cheon, AeRan; Park, Gye Shin; Park, Hyeong Soon; Pang, Choo Young; (31 pag.)KR101583811; (2016); B1;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

Ferrocenemethanol, cas is 1273-86-5, it is a common heterocyclic compound, the iron-catalyst compound, its synthesis route is as follows.,1273-86-5

General procedure: Method A (Table 2, entries 1,4). Into a glass 50-mL flask equipped with a stirrer, a reflux condenser,a thermometer, a bubbler for propyne supply, and a gasoutlet, alcohol 1a,b (5.0 mmol), KPO0.5O2P (0.16 g, 2.5 mmol),and DMSO (30 mL) were placed. Propyne was passed on stirring for2 h through the reaction mixture heated up to 80 C. After coolingto room temperature the reaction mixture was diluted with anaqueous 1% solution of NH4Cl (50 mL) and extracted with ether(530 mL), the extracts were washed from DMSO by water(230 mL), dried over Na2SO4. Column chromatography (basicAl2O3, eluent hexane/diethyl ether with gradient from 1:0 to 3:1) ofthe crude residue after removal of the solvent gave the pure adducts2c,d and unreacted alcohols 1a,b.

As the rapid development of chemical substances, we look forward to future research findings about 1273-86-5

Reference£º
Article; Trofimov, Boris A.; Oparina, Ludmila A.; Tarasova, Olga A.; Artem’ev, Alexander V.; Kobychev, Vladimir B.; Gatilov, Yuriy V.; Albanov, Alexander I.; Gusarova, Nina K.; Tetrahedron; vol. 70; 35; (2014); p. 5954 – 5960;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

1273-86-5, Ferrocenemethanol is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a Schlenk tube, 1.00 g (4.63 mmol) of ferrocenyl methanol and 0.47 mL(4.7 mmol) of 2,4 pentanedione were dissolved in 8 mL of acetonitrile at room temperature (rt). After 5 min of stirring, 0.125 g (0.23 mmol) of cerium(IV)ammonium nitrate (5% molar) were added. The reaction mixture was stirred for 30 min at rt and then evaporated under reduced pressure. The solid residue was mixed with 5 mL of water and extracted with 10 mL of dichloromethane.The organic phase was dried over MgSO4, filtered off and evaporated under reduced pressure to afford 1.25 g (4.29 mmol, 90% yield) of 1 as an orange oil.

1273-86-5, As the paragraph descriping shows that 1273-86-5 is playing an increasingly important role.

Reference£º
Article; Ahumada, Guillermo; Roisnel, Thierry; Hamon, Jean-Rene; Carrillo, David; Manzur, Carolina; Journal of the Chilean Chemical Society; vol. 58; 4; (2013); p. 1963 – 1966;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

Ferrocenemethanol, cas is 1273-86-5, it is a common heterocyclic compound, the iron-catalyst compound, its synthesis route is as follows.,1273-86-5

To a 10 ml Schlek reaction tube under a high-purity nitrogen atmosphere was added 0.20 mmol of benzoquinoline triphenylphosphine iridium hydrogen (16), lmmol of phenylacetylene, 2.3 mmol of ferrocene methanol, 0.8 mmol of sodium hydroxide and 3 ml of dioxane were charged. The reaction tube was replaced with nitrogen three times and then heated to 110 C with an oil bath under magnetic stirring. The reaction was refluxed for 36 hours. The filtrate was concentrated using a rotary evaporator and the remaining residue was purified by chromatography on oil (100 mL). The residue was purified by flash chromatography on silica gel eluting with an oil bath and the bath was cooled to room temperature. Ether as eluent, and separated by silica gel thin layer chromatography to obtain pure product 1-ferrocenyl-3-phenyl-1-propanone in a yield of 96%.

As the rapid development of chemical substances, we look forward to future research findings about 1273-86-5

Reference£º
Patent; Luoyang Normal University; Li, Xiao Dong; Li, gongmei; Xu, Chen; Hao, Xin Qi; Xiao, Zhi Qiang; (10 pag.)CN103242372; (2016); B;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1273-86-5,Ferrocenemethanol,as a common compound, the synthetic route is as follows.

General procedure: To a mixture of 1.0 mmol of ferrocenylcarbinol and 1.0 mmol of the corresponding heterocycle in 1.0 ml of methylene dichloride, 0.18 ml of 45 % aqueous solution of fluoroboric acid was added under vigorous stirring. The agitation was continued for 5 min then Et2O (15 ml), the same amount of cold water, and 5-10 mg of ascorbic acid were added to the reaction flask. After vigorous shaking of the mixture the organic solution was separated, washed with cold water (3¡Á15 ml), the solvent was removed and the residue was dried over CaCl2. All types of products (pyrrolidine as well as imidazolidine and thiazolidine derivatives) were equally purified, namely by column chromatography (silica, eluent hexane EtOAc 3:1), and solids obtained after chromatography were crystalized from ethanol.

1273-86-5, The synthetic route of 1273-86-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Rogatkina, Elena Yu.; Ivanova, Anna S.; Rodionov, Alexey N.; Peregudov, Alexander S.; Korlyukov, Alexander A.; Volodin, Alexander D.; Belousov, Yury A.; Simenel, Alexander A.; Arkivoc; vol. 2018; 5; (2018); p. 272 – 282;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

Ferrocenemethanol, cas is 1273-86-5, it is a common heterocyclic compound, the iron-catalyst compound, its synthesis route is as follows.,1273-86-5

Compound hydroxymethylferrocene S5 (1 g, 4.63 mmol),1-chloro-3,5-di-p-chlorobenzoyloxy-2-deOxygen-D-ribose S6 (1.79 g, 4.17 mmol),Anhydrous Cs2CO3 (2.60 g, 7.87 mmol) was dissolved in anhydrous dichloromethane.Stir at room temperature overnight, and vortex off the solvent.Silica gel column chromatography(Dichloromethane: methanol = 95:5) was purified to give an orange-red compound S7 (yield: 80%).

As the rapid development of chemical substances, we look forward to future research findings about 1273-86-5

Reference£º
Patent; Hunan University; Tan Weihong; A Budula¡¤lazhate¡¤moyideng; (23 pag.)CN109265486; (2019); A;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

1273-86-5, Ferrocenemethanol is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Amine (1.0mmol), In(OTf)3 (0.1mmol) and anisyl alcohol (1.2mmol) were added into a flask. Then the mixture was vigorously stirred at reflux, until amine was completely consumed as indicated by TLC analysis or 24h. After the completion of reaction, CH2Cl2 (15mL¡Á2) was used to extract the product, the organic layer was dried with anhydrous Na2SO4. Then the solvent was evaporated under the reduced pressure. The residue was purified by flash column chromatography with ethyl acetate and petroleum ether as eluents to afford pure product. This procedure was followed for the synthesis of other N-benzylation amines.

1273-86-5, 1273-86-5 Ferrocenemethanol 10856885, airon-catalyst compound, is more and more widely used in various fields.

Reference£º
Article; Yang, Jin-Ming; Jiang, Ran; Wu, Lin; Xu, Xiao-Ping; Wang, Shun-Yi; Ji, Shun-Jun; Tetrahedron; vol. 69; 37; (2013); p. 7988 – 7994;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1273-86-5,Ferrocenemethanol,as a common compound, the synthetic route is as follows.

General procedure: Method A (Table 2, entries 1,4). Into a glass 50-mL flask equipped with a stirrer, a reflux condenser,a thermometer, a bubbler for propyne supply, and a gasoutlet, alcohol 1a,b (5.0 mmol), KPO0.5O2P (0.16 g, 2.5 mmol),and DMSO (30 mL) were placed. Propyne was passed on stirring for2 h through the reaction mixture heated up to 80 C. After coolingto room temperature the reaction mixture was diluted with anaqueous 1% solution of NH4Cl (50 mL) and extracted with ether(530 mL), the extracts were washed from DMSO by water(230 mL), dried over Na2SO4. Column chromatography (basicAl2O3, eluent hexane/diethyl ether with gradient from 1:0 to 3:1) ofthe crude residue after removal of the solvent gave the pure adducts2c,d and unreacted alcohols 1a,b.

1273-86-5, The synthetic route of 1273-86-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Trofimov, Boris A.; Oparina, Ludmila A.; Tarasova, Olga A.; Artem’ev, Alexander V.; Kobychev, Vladimir B.; Gatilov, Yuriy V.; Albanov, Alexander I.; Gusarova, Nina K.; Tetrahedron; vol. 70; 35; (2014); p. 5954 – 5960;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

1273-86-5, Ferrocenemethanol is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Method A (Table 1, entries 4, 5). A mixture of alcohol1a,b (30 mmol) and KPO0.5O2P (0.20 g, 3 mmol) in DMSO(50 mL) was placed into a 0.3-L Parr-reactor. The latter was fed withacetylene and then decompressed to atmospheric pressure toremove air. The autoclave was fed with acetylene again (initialpressure at ambient temperature was 13 atm) and heated (70 C)upon stirring for 0.75 or 1 h. The reaction mixture, after cooling toroom temperature, was diluted with an aqueous 1% solution ofNH4Cl (50 mL). The aqueous layer was extracted with diethyl ether(20 mL6), the extracts were washed with water (15 mL3) anddried (Na2SO4). Column chromatography (basic Al2O3, eluent hexane/diethyl ether with gradient from 1:0 to 1:1) of the crude residueafter removal of the solvent gave the pure adducts 2a,b andunreacted alcohols 1a,b.

1273-86-5, 1273-86-5 Ferrocenemethanol 10856885, airon-catalyst compound, is more and more widely used in various fields.

Reference£º
Article; Trofimov, Boris A.; Oparina, Ludmila A.; Tarasova, Olga A.; Artem’ev, Alexander V.; Kobychev, Vladimir B.; Gatilov, Yuriy V.; Albanov, Alexander I.; Gusarova, Nina K.; Tetrahedron; vol. 70; 35; (2014); p. 5954 – 5960;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

The iron-catalyst compound, cas is 1273-86-5 name is Ferrocenemethanol, mainly used in chemical industry, its synthesis route is as follows.,1273-86-5

Acetophenone (60 mg, 0.5 mmol),Cat. [Ir] (5.4 mg, 0.005 mmol, 1.0 mol%),Cesium carbonate (33 mg, 0.1 mmol, 0.2 equiv.),Ferrocene methanol (130 mg, 0.6 mmol)And tert-amyl alcohol (1 ml) were successively added to a 5 mL round bottom flask.The reaction mixture was refluxed in air for 12 hours,Cool to room temperature.Rotate the solvent to remove the solvent,The purified title compound was then purified by column chromatography (developing solvent: petroleum ether / ethyl acetate)Yield: 92%

With the rapid development of chemical substances, we look forward to future research findings about 1273-86-5

Reference£º
Patent; Nanjing University of Science and Technology; Liu, Pengcheng; Lu, Lei; Li, Feng; (12 pag.)CN106478395; (2017); A;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion