Irreversible inhibitors are therefore the equivalent of poisons in heterogeneous catalysis. Safety of Ferrocenemethanol, Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction by binding to a specific portion of an enzyme and thus slowing or preventing a reaction from occurring. In a patent，Which mentioned a new discovery about 1273-86-5
The reactions of ferrocenyl methanol, ferrocenyl 2-propanol and N-methyl-2-ferrocenylmethylamine with chlorocyclophosphazenes have been examined. The pentachlorocyclotriphosphazene derivative of ferrocenylmethanol undergoes rapid decomposition via a phosphazene-phosphazane rearrangement, however when the alcohol function is beta to the cyclopentadienyl ring modest yields of N3P3Cl5OCHMeCH2C5H 4FeCp may be obtained. By way of contrast N-methyl-2-ferrocenylmethylamine gives a broad range of stable derivatives, N3P3Cl6-n[NMeCH2C5H 4FeCp]n(n=1-3). The substitution process follows a predominantly trans non-geminal pathway. The corresponding reaction with the butylmethacrylate derivative, N3P3Cl5O(CH2) 4OC(O)CMe=CH2 leads to the unexpected geminal product, 2,2?-N3P3Cl4[O(CH2) 4OC(O)CMe=CH2]NMeCH2C5H 4FeCp. Polymers containing the 2-ferrocenylmethylamine function have been obtained by reactions of poly(dichlorophosphazene) with the ferrocenylamine and by radical addition polymerization of the aforementioned mixed ferrocenylamino butylmethacrylphosphazene. The new materials have been characterized by standard methologies including 31P NMR spectroscopy, cyclic voltametry and gel permeation chromatography.
Reactions of ferrocenyl amines and alcohols with hexachlorocyclotriphosphazene
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Reference：
Iron Catalysis in Organic Synthesis | Chemical Reviews,
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion